Researchers carried out a research to check as soon as-weekly semaglutide 1.zero mg with exenatide prolonged launch (ER) 2.zero mg in sufferers with sort 2 diabetes to see about their security and effectiveness.
Semaglutide as soon as-weekly is within the GLP-1 receptor agonist class of diabetes medicine marketed as Ozempic by Novo Nordisk for the remedy of sort 2 diabetes in adults.
Exenatide ER is additionally a as soon as-weekly GLP-1 receptor agonist marketed as Bydureon by AstraZeneca for sort 2 diabetes remedy.
The researchers lead a section 3a, open-label, parallel-group, randomized managed trial with 813 members with sort 2 diabetes taking oral diabetes medicines. These sufferers have been randomly chosen to take both semaglutide 1.zero mg or exenatide ER 2.zero mg for 56 weeks complete.
The predominant object was to take a look at modifications in A1c ranges between the beginning of the trial and week 56.
Which Diabetes Drug Was Safer and More Effective?
Mean A1c at baseline among the many members was eight.three%. According to this research’s outcomes, these on semaglutide lowered the imply A1c ranges by 1.5% and people on exenatide ER by .9%.
Regarding physique weight of the members, imply physique weight was 95.eight kg at baseline and that imply was diminished by 5.6 kg with semaglutide and 1.9 kg with exenatide ER.
How lots of the members received their A1c underneath 7%? 67% of these taking semaglutide and solely 40% of these on exenatide ER.
The researchers say that each remedies “had similar safety profiles, but gastrointestinal adverse events were more common in semaglutide-treated subjects (41.8%) than in exenatide ER–treated subjects (33.3%)” Also, reactions on the injection-web site have been extra frequent for these on exenatide ER (22%) than these with semaglutide (1.2%
The research authors conclude that the superior drug based on this research got here out to be semaglutide 1.zero mg when it got here to enhancing blood sugars and lowering physique weight after 56 weeks. The two medicine are related when it comes to security profiles.
“These results indicate that semaglutide treatment is highly effective for subjects with type 2 diabetes who are inadequately controlled on oral antidiabetic drugs,” state the authors.
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Read extra about A1c, AstraZeneca, exenatide, GLP-1, Novo Nordisk, Ozempic (semaglutide), sort 2 diabetes medicine.